منابع مشابه
Radical Smiles Rearrangement: An Update.
Over the decades the Smiles rearrangement and its variants have become essential synthetic tools in modern synthetic organic chemistry. In this mini-review we summarized some very recent results of the radical version of these rearrangements. The selected examples illustrate the synthetic power of this approach, especially if it is incorporated into a domino process, for the preparation of poly...
متن کاملFirst domino radical cyclisation/Smiles rearrangement combination.
An unprecedented domino radical cyclisation-Smiles rearrangement process affording 3-(2'-aryl-N-methyl acetamido)indolin-2-ones is presented. Experimental rationalisation of this approach and description of an unexpected tricyclic core are also handled.
متن کاملSmiles Counting the Smiles
This research summary, based on a review of the literature and a series of focus groups with NHS staff, shows that while it is difficult to measure how people feel about their work, there is much to suggest that morale and motivation of the NHS workforce are low. It identifies three key factors that affect morale and motivation: whether staff feel valued, their working environment, and resource...
متن کاملSmiles Rearrangement in the Synthesis of Di- and Triiodinated 5- (Acylamino)-1,3-Benzenedicarboxamides
Both the number and the position of iodine atoms on the aromatic ring of polyiodinated N,N’-bis(2,3dihydroxypropyl)-5-[2-methylamino-2-oxoethoxy]-1,3-benzenedicarboxamides are crucial to define the structure of the product obtained by treatment with aqueous NaOH. The 2,6-diiodo and the 2,4,6-triiodo derivatives give the corresponding Smiles rearrangement products in 77 and 96% yields, respectiv...
متن کاملElectrophile-Integrating Smiles Rearrangement Provides Previously Inaccessible C4′-O-Alkyl Heptamethine Cyanine Fluorophores
New synthetic methods to rapidly access useful fluorophores are needed to advance modern molecular imaging techniques. A new variant of the classical Smiles rearrangement is reported that enables the efficient synthesis of previously inaccessible C4'-O-alkyl heptamethine cyanines. The key reaction involves N- to O-transposition with selective electrophile incorporation on nitrogen. A representa...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1972
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.20.607