The DNA-Binding Protein CTCF Limits Proximal Vκ Recombination and Restricts κ Enhancer Interactions to the Immunoglobulin κ Light Chain Locus
نویسندگان
چکیده
منابع مشابه
Important Roles for E Protein Binding Sites within the Immunoglobulin κ Chain Intronic Enhancer in Activating Vκ Jκ Rearrangement
The immunoglobulin kappa light chain intronic enhancer (iEkappa) activates kappa rearrangement and is required to maintain the earlier or more efficient rearrangement of kappa versus lambda (lambda). To understand the mechanism of how iEkappa regulates kappa rearrangement, we employed homologous recombination to mutate individual functional motifs within iE(kappa) in the endogenous kappa locus,...
متن کاملNF-κB and the Immunoglobulin κ Gene Enhancer
Enhancers regulate lineage choice and the developmental timing of antigen receptor gene rearrangements. The transcription factor NF-kappaB has been implicated as a key component of the recombination and transcription activation potential of the immunoglobulin kappa chain gene intronic enhancer. Here, I discuss the implications of the new observation that an NF-kappaB binding site-mutated enhanc...
متن کاملBiallelic Germline Transcription at the κ Immunoglobulin Locus
Rearrangement of antigen receptor genes generates a vast array of antigen receptors on lymphocytes. The establishment of allelic exclusion in immunoglobulin genes requires differential treatment of the two sequence identical alleles. In the case of the kappa immunoglobulin locus, changes in chromatin structure, methylation, and replication timing of the two alleles are all potentially involved ...
متن کاملDiscrete renal deposition of IgM heavy chain and κ light chain in Waldenström macroglobulinemia (IgM-κ)
We report previously undescribed renal lesions associated with monoclonal gammopathy in a 59-year-old man with Waldenström macroglobulinemia (IgM-κ). Light microscopy showed mesangial proliferation and thickening of glomerular basement membranes (GBMs) and tubular basement membranes (TBMs). Neither intraglomerular thrombi nor nodular glomerulosclerosis was observed. Immunofluorescence studies d...
متن کاملComparison of free κ and λ light chain immunoassays and total (bound and free) κ and λ light chain immunoassays.
Comparison of free κ and λ light chain immunoassays and total (bound and free) κ and λ light chain immunoassays To the editor: We read, with interest, the article by Dr. Zamora-Ortiz, et al. Poor performance of the total kappa/ lambda light chain quantification in the diagnosis and follow-up of patients with multiple myeloma on the comparison of the total serum light chain assay (sLC), SPE and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Immunity
سال: 2011
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2011.07.014