منابع مشابه
Digitalis.
Cardiac glycosides have played a prominent role in the therapy of congestive heart failure since William Withering codified their use in his late 18th century monograph on the efficacy of the leaves of the common foxglove plant (Digitalis purpurea). Despite their widespread acceptance into medical practice in the ensuing 200 years, both the efficacy and the safety of this class of drugs continu...
متن کاملThe Foxgloves (Digitalis) Revisited.
This review provides a renewed look at the genus Digitalis. Emphasis will be put on those issues that attracted the most attention or even went through paradigmatic changes since the turn of the millennium. PubMed and Google Scholar were used ("Digitalis" and "Foxglove" were the key words) to identify research from 2000 till 2017 containing data relevant enough to be presented here. Intriguing ...
متن کاملDigitalis cardiotoxicity.
Clinical manifestations of digitalis toxicity were clearly described by Withering in 1785. One hundred years later, certain digitalis-induced arrhythmias were inscribed on the smoked drum, and shortly thereafter with the introduction of the electrocardiograph, manifestations of digitalis toxicity as recognized today were recorded in animals and human beings. With popularization of the direct-wr...
متن کاملDigitalis toxicity.
Digitalis toxicity is a frequently encountered clinical problem. Drug interactions leading to digitalis toxicity are very common. Within this group, the interaction of digitalis and verapamil is increasingly recognized as an important cause of digitalis toxicity. The use of digoxin-binding antibodies represents a significant advance in the treatment of this problem and can be lifesaving in the ...
متن کاملIs ouabain the endogenous digitalis?
T he possibility that an endogenous ligand might exist for the cardiac glycoside binding site on the Na+,K+-ATPase (i.e., the "sodium pump") has been a source of much speculation, resulting in intensive efforts over the past decade by many laboratories to identify an "endogenous digitalis-like hormone."'1-6 Several arguments have been propounded in support of this hypothesis. The first and perh...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1933
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)76019-5