The diffuse reduction in spleen density: an indicator of severe acute pancreatitis?

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The diffuse reduction in spleen density: an indicator of severe acute pancreatitis?

We observed that acute pancreatitis (AP) was associated with diffuse reduction in spleen density (DROSD) in some patients. Furthermore, the condition of these patients was more serious, and the potential relationship between DROSD and structural and functional injury of the spleen remained unclear. Therefore, we performed a preliminary exploration of these factors. We analysed pertinent clinica...

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The Immunomodulatory Effects and Mechanisms of Tim-3 Action in the Early Stage of Mice with Severe Acute Pancreatitis

Background: Tim-3 has been considered as an ideal target for the immunotherapy of inflammation, but it is unclear whether Tim-3 also plays an important role in acute pancreatitis (AP), as well. Objective: To identify the immunomodulatory effects and mechanisms of Tim-3 action in the early stages of severe acute pancreatitis in mice. Methods: Ma...

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Severe acute pancreatitis

Pancreatitis is an inflammatory disorder of the pancreas which occurs with an estimated incidence of 10–40 per 100 000 per year in the UK. Mild acute (oedematous or interstitial) pancreatitis accounts for 80% of cases, is self-limiting, and usually resolves with simple supportive management in 3–5 days. Severe acute pancreatitis (SAP) accounts for the remainder of cases and was defined by the A...

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ژورنال

عنوان ژورنال: Bioscience Reports

سال: 2017

ISSN: 0144-8463,1573-4935

DOI: 10.1042/bsr20160418