The Diabetes-Cancer Link
نویسندگان
چکیده
منابع مشابه
The Diabetes-Cancer Link
Type 2 diabetes is associated with increased risks for several cancers, including colon,1 postmenopausal breast,2 pancreatic,3 liver,4 endometrial,5 and bladder6 cancers and non-Hodgkins lymphoma.7 Type 2 diabetes is also linked to a modest decrease in the risk for prostate cancer.8 However, diabetes does not reduce aggressive forms, and prostate cancer mortality rates are higher among men with...
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The recent recognition of the clinical association between type 2 diabetes (T2D) and several types of human cancer has been further highlighted by reports of antidiabetic drugs treating or promoting cancer. At the cellular level, a plethora of molecules operating within distinct signaling pathways suggests cross-talk between the multiple pathways at the interface of the diabetes-cancer link. Ad...
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O-linked β-N-acetylglucosamine (O-GlcNAc) is a sugar attachment to serine or threonine hydroxyl moieties on nuclear and cytoplasmic proteins. In many ways, O-GlcNAcylation is similar to phosphorylation because both post-translational modifications cycle rapidly in response to internal or environmental cues. O-GlcNAcylated proteins are involved in transcription, translation, cytoskeletal assembl...
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Ralph N. Martinsa,b,c,d,e,∗ aSchool of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia bDepartment of Biomedical Sciences, Macquarie University, Sydney, NSW, Australia cKaRa Institute of Neurological Diseases, Sydney, NSW, Australia dAustralian Alzheimer’s Research Foundation Perth, WA, Australia eSchool of Psychiatry and Clinical Neurosciences, University of Western A...
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Vitamin A has a critical role in embryonic development, immunity and the visual cycle. In recent years, evidence has demonstrated that vitamin A can also regulate metabolic pathways implicated in the pathogenesis of obesity and diabetes. This has increased interest in the possible antiobesity and antidiabetic properties of natural and synthetic vitamin A derivatives. However, whether vitamin A ...
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ژورنال
عنوان ژورنال: Diabetes Spectrum
سال: 2014
ISSN: 1040-9165,1944-7353
DOI: 10.2337/diaspect.27.4.276