The development of flagellate hyperpigmentation after use of bleomycin for sclerotherapy slow flow vascular malformations

Introduction . Bleomycin is a cytotoxic antibiotic that used as sclerosing agent for sclerotherapy of vascular anomalies. characterized by complications: nausea, vomiting, fever, the development allergies/anaphylaxis, skin discoloration (hyperpigmentation), damage to lung tissue. Aim To study frequency hyperpigmentation after administration bleomycin malformations with slow flow characteristics. present our own clinical observation venous malformation bleomycin. Materials and methods A systematic review was conducted in foreign (PubMed, Web Of Science, Google Scholar, Scirus) domestic databases (eLibrary) period from 2012 2022. As result selection, 17 full-text articles remained suitable their inclusion analysis. Results In first part review, 12 were analyzed, describing observations “flaggelate” chemotherapy various neoplasms. second an analysis 4 intralesional into 19 patients carried out. Discussion. The occurrence specific anomalies characteristics rare complication. out, there no clear connection between excess dosage. Conclusion prevent appearance hyperpigmentation, it necessary avoid excessive traumatization on time immediately sclerotherapy, including ECG electrodes; oxygenation during provision anesthesia; insolation within 24–48 hours sclerotherapy.