The dalmatian defect: A hepatic endocrinopathy of urate transport
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چکیده
منابع مشابه
Nucleotide metabolism and Urate excretion in the Dalmatian dog breed
The purpose of this literature study is to give an overview of nitrogen and purine metabolism in general and in particular of the molecular mechanisms for the higher uric acid excretion in Dalmatian dogs. The character portrayed by the Dalmatian breed appears to be connected whit a malfunction within purine metabolism, some studies point at a kidney disease whereas other at a liver disease. Alt...
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1. The renal mechanism for urate excretion in the Dalmatian dog resembles that in birds. Urate is cleared at a rate considerably greater than the glomerular filtration rate, indicating that its excretion is the result of both glomerular filtration and active tubular secretion. The basic physiological mechanisms involved in the anomalous purine metabolism of the Dalmatian are indicated and their...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 2005
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.21241