The cytotoxic activity of Sponges and Tunicates from Turkish Aegean Sea

The enormous bioactive components of different species from marine habitats make them attractive candidates for the discovery new therapeutic active substances in several diseases such as cancer. Sea sponge and tunicate materials are ideal sources chemotherapeutics various cancers due to their rich metabolites. fundamental purpose current study is investigate cytotoxic activity methanolic crude extracts sponges (Agelas oroides Cladocora caespitosa) tunicates (Ascidiella aspersa and Styela clava) collected Aegean Sea. anti-cancer was carried out by sodium 3´- [1- (diphenyl aminocarbonyl)-3,4-tetrazolium] -bis (4-methoxy 6-nitro) benzene sulfonic acid hydrate (XTT) on gastric adenocarcinoma cell line AGS, prostate cancer PC-3, neuroblastoma SH-SY5Y, mouse fibroblast L929. were found cause effects cells, largely a concentration-dependent manner. It that exhibited high activities lines at concentrations 3 5 mg/ml. No significant L929 cells. In addition, microscopic examination cells treated with shows morphological changes cellular rounding, which could be associated apoptosis.