The CVC and CRBSI: don’t use it and lose it!

Use it or lose it! But use it wisely.

reasons to fit hearing aids bilaterally: better sound localization and better speech understanding in background noise. To be sure, some elderly persons may do better when fitted monaurally, perhaps due to an age-related interaural interference effect, but these two principal advantages of bilateral fittings have been demonstrated many times over in the majority of hearing aid users. In this is...

Conventional Voxel in Tomographic Reconstruction Based upon Plane-Integral Projections – Use It or Lose It?

Introduction: While the necessity of replacing voxels with blobs in conventional tomographic reconstruction based upon line-integrals is clear, it is not however well-investigated in plane- integral-based reconstruction. The problem is more challenging in convergent-plane projection reconstruction. In this work, we are aiming at utilizing blobs as alternative to voxels. <stron...

Lose It? Telomerase in T Lymphocytes: Use It And

Brain aging and Alzheimer's disease; use it or lose it.

(1) Alzheimer's disease is a multifactorial disease in which age and APOE-epsilon 4 are important risk factors. (2) The neuropathological hallmarks of AD, i.e. amorphous plaques, neuritic plaques (NPs), pretangles, neurofibrillary tangles (NFT) and cell death are not part of a single pathogenetic cascade but may occur independently. (3) In brain areas where classical AD changes, i.e. NPs and NF...

Cytoplasmic mRNA: move it, use it or lose it!

Once an mRNA is synthesized and processed, the immediate translation and later destruction of the transcript is not as inevitable as the central molecular biology dogma suggests. Interest in the field of post-transcriptional control continues to grow rapidly, as regulation of these multiple steps in gene expression is implicated in diverse aspects of biology such as metabolism, neurology, repro...