The Coupling between Epilepsy and Cortical Spreading Depression of Leão
نویسندگان
چکیده
Objectives: The discovery of cortical spreading depression 80 years ago by Leão was intimately connected to epilepsy research. In our studies we found that monitoring brain hemodynamics, metabolic ionic and electrical activities are very similar in the two pathophysiological events. Here presenting coupling between while mitochondrial nicotinamide adenine dinucleotide-NADH together with other physiological parameters real time vivo. Methods: Rats Mongolian gerbils were used three models induction epilepsy, namely injection pentylenetetrazol-metrazol, exposure rats hyperbaric oxygenation a pressure chamber using strain developing seizures spontaneously. We monitored oxygen levels, NADH, extracellular potassium Direct Current-DC steady potential electroencephalography-EEG slightly anesthetized animals. Results: results could be summarized as follows: 1. almost all animal tested developed recorded after 1-3 minutes activity. 2. Mitochondrial NADH redox state more oxidized during 3. oxidation Cortical Spreading Depression- CSD 3-4 times relative seizure’s interval. 4. increase levels also higher event. Significance: Under events clear correlation process (energy) demand or consumption supply found. suggest accumulation epileptic activity is probably trigger for development 3 model used.
منابع مشابه
Professor Aristides Leão. Much more than spreading depression.
Professor Leão described cortical spreading depression (CSD) in 1944 and changed the way migraine pathophysiology is scientifically conceived. This Brazilian professor and researcher developed his career in Rio de Janeiro. Because of him, the city once became the CSD world capital, attracting scientists from many laboratories around the globe. Aristides Leão was first and foremost a naturalist,...
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Migraine is a disorder that afflicts nearly one tenth of the population. Involving both nervous and vascular system, it has been found as a prominent factor of disability. The migraine attacks may be initiated in the brainstem or may begin peripherally in the meninges while the role of cortical activation preceding an attack is also debated. Although available treatments, more studies on migrai...
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ژورنال
عنوان ژورنال: Medical research archives
سال: 2023
ISSN: ['2375-1916', '2375-1924']
DOI: https://doi.org/10.18103/mra.v11i7.1.4122