The contribution of FTO rs9939609 and RETN rs1862513 polymorphisms in predisposing resettled indigenous (Orang Asli) Temiar to metabolic syndrome

Abstract Purpose Metabolic syndrome (MetS) is characterized by visceral obesity, elevated blood pressure and fasting glucose, increased triglycerides, lower high-density lipoprotein cholesterol. MetS related with intricate gene-environment interactions. FTO RETN variants were linked to the occurrence of MetS, but inconsistent results reported. Therefore, this study was conducted evaluate potential role rs9939609 rs1862513 polymorphisms their susceptibility risk among resettled indigenous or Orang Asli (OA) Temiar subtribe under resettlement scheme Malaysia government. Methods A cross sectional performed involving 123 volunteers located in Gua Musang, Kelantan. identified using modified NCEP-ATP III. DNA extraction done peripheral blood. Polymerase Chain Reaction–Restriction Fragment Length Polymorphism (PCR–RFLP) employed genotype polymorphisms. Susceptibility ( rs1862513) determined binary logistic regression analysis odds ratios (ORs). Results associated estimated OR 19.9 P < 0.001) 20.7 = 0.006) for heterozygous (T/A) homozygous (A/A) at locus, respectively; 222.5 26.2 0.005) (C/G) (G/G) respectively. Conclusion The genetic subtribe. findings contribute toward fundamental prevention plan decrease probability development.