The connexins
نویسندگان
چکیده
منابع مشابه
Connexins and the kidney.
Connexins (Cxs) are widely-expressed proteins that form gap junctions in most organs, including the kidney. In the renal vasculature, Cx37, Cx40, Cx43, and Cx45 are expressed, with predominant expression of Cx40 in the endothelial cells and Cx45 in the vascular smooth muscle cells. In the tubules, there is morphological evidence for the presence of gap junction plaques only in the proximal tubu...
متن کاملConnexins in the Nervous System
This chapter reviews the localizations and physiological roles of connexins in neurons and glia of the central and peripheral nervous systems. Cx32 forms gap junctions in noncompact myelin in Schwann cells, which are thought to form a reflexive communication pathway connecting the outer and inner myelin layers. Cx29 is also expressed in myelinating Schwann cells, but does not appear to form gap...
متن کاملWhich connexins connect?
Electrical signaling via gap junctions modulates vascular function via 2 physiologically interrelated mechanisms, namely dilations/constrictions that propagate longitudinally along the vessel wall,1–4 and the EDHF phenomenon, in which relaxation is facilitated by the transmission of endothelial hyperpolarization to smooth muscle via a radial myoendothelial pathway.5 Gap junctions are composed f...
متن کاملConnexins are mechanosensitive.
Connexins form gap junction channels that provide a hydrophilic path between cell interiors. Some connexins, particularly the lens connexins, Cx46 and Cx50 and their orthologs, can form functional hemichannels in nonjunctional membranes. These hemichannels are a nonselective conduit to the extracellular medium and may jeopardize cell survival. The physiological function of hemichannels has rema...
متن کاملConnexins and Diabetes
Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which are further assembled from proteins called "connexins." In this paper, we discuss current knowledge about connexins in diabetes. We also discuss mechanisms ...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2004
ISSN: 0005-2736
DOI: 10.1016/j.bbamem.2004.02.001