The complement system and age-related macular degeneration
نویسندگان
چکیده
منابع مشابه
Complement inhibitors for age-related macular degeneration.
BACKGROUND Given the relatively high prevalence of age-related macular degeneration (AMD) and the increased incidence of AMD as populations age, the results of trials of novel treatments are awaited with much anticipation. The complement cascade describes a series of proteolytic reactions occurring throughout the body that generate proteins with a variety of roles including the initiation and p...
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Introduction: Age-related macular degeneration (AMD) is one of the major causes of visual loss among the elderly. It causes degeneration of cells in the macula. Early diagnosis can be helpful in preventing blindness. Drusen are the initial symptoms of AMD. Since drusen have a wide variety, locating them in screening images is difficult and time-consuming. An automated digital fundus photography...
متن کاملThe complement component 5 gene and age-related macular degeneration.
OBJECTIVE To investigate the association between variants in the complement component 5 (C5) gene and age-related macular degeneration (AMD). DESIGN Separate and combined data from 3 large AMD case-control studies and a prospective population-based study (The Rotterdam Study). PARTICIPANTS A total of 2599 AMD cases and 3458 ethnically matched controls. METHODS Fifteen single nucleotide po...
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age-related macular degeneration (amd) is the leading cause of blindness in old subjects. it is a multifactorial disease with both environmental and genetic factors playing some role in its pathogenesis. similar to many other genetic diseases, the inheritance pattern of amd does not fit into simple mendelian rules. these diseases are caused by the presence of multiple genetic factors and are ca...
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Age-related macular degeneration (AMD) is a common, late-onset, and complex trait with multiple risk factors. Concentrating on a region harboring a locus for AMD on 1q25-31, the ARMD1 locus, we tested single-nucleotide polymorphisms for association with AMD in two independent case-control populations. Significant association (P = 4.95 x 10(-10)) was identified within the regulation of complemen...
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ژورنال
عنوان ژورنال: Eye
سال: 2006
ISSN: 0950-222X,1476-5454
DOI: 10.1038/sj.eye.6702176