منابع مشابه
Dmd051631 1264..1272
Ketamine is primarily metabolized to norketamine by hepatic CYP2B6 and CYP3A4-mediated N-demethylation. However, the relative contribution from each enzyme remains controversial. The CYP2B6*6 allele is associated with reduced enzyme expression and activity that may lead to interindividual variability in ketamine metabolism. We examined the N-demethylation of individual ketamine enantiomers usin...
متن کاملDmm021105 1255..1264
Deconvoluting the molecular target signals behind observed drug response phenotypes is an important part of phenotype-based drug discovery and repurposing efforts. We demonstrate here how our network-based deconvolution approach, named target addiction score (TAS), provides insights into the functional importance of druggable protein targets in cell-based drug sensitivity testing experiments. U...
متن کاملOwner-Reported Response to Treatment of 130 Headshaking Horses
Nose nets, face masks, and magnesium supplementation were the most efficacious nonmedical therapies for treatment of headshaking. Of the pharmacological treatments, cyproheptadine, corticosteroids, and melatonin resulted in greatest improvement. Each of these treatments resulted in improvement in approximately 50% of headshaking horses. Authors’ addresses: Department of Veterinary Medicine and ...
متن کاملAORTIC VALVULOTOMY IN NEONATES/Edmunds
tic regurgitation using afterload stress. Circulation 53: 132, 1976 51. Borer JS, Bacharach SL, Green MV, Kent KM, Henry WL, Rosing DR, Seides SF, Johnston GS, Epstein SE: Exerciseinduced left ventricular dysfunction in symptomatic and asymptomatic patients with aortic regurgitation: assessment with radionuclide cineangiography. Am J Cardiol 42: 351, 1978 52. Papadimitriou JM, Hopkins BE, Taylo...
متن کاملThe Genetics of Schizophyllum Commune.
URING the course of an investigation on sexuality and related phenomena Din the common wood-rotting mushroom, Schizophyllum commune, a continuing search has been maintained for appropriate genetic markers for use in the work. A wide variety of morphologically aberrant and biochemically deficient strains has accordingly been tested for single locus segregation and for possible linkage with the f...
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ژورنال
عنوان ژورنال: The English Historical Review
سال: 1909
ISSN: 0013-8266,1477-4534
DOI: 10.1093/ehr/xxiv.xciv.313