The Clinical Pharmacology of Cladribine Tablets for the Treatment of Relapsing Multiple Sclerosis
نویسندگان
چکیده
منابع مشابه
Cladribine tablets for the treatment of relapsing-remitting multiple sclerosis.
INTRODUCTION Multiple sclerosis (MS) is a chronic immune-mediated disorder of the central nervous system leading to progressive neurodegeneration and disability. Until 2010, all approved disease-modifying drugs for MS required parenteral administration, which is associated with suboptimal adherence. It was anticipated that new approaches to treatment, including oral agents such as cladribine ta...
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15 صفحه اولCladribine in the treatment of multiple sclerosis
ISSN 2041-6792 10.4155/CLI.10.32 © 2011 Future Science Ltd Treatment with cladribine leads to a preferential and sustained reduction in lymphocytes and monocytes, resulting in long-lasting depletion of CD4+ and CD8+ T cells. In the Phase III placebo-controlled trial in relapsing–remitting multiple sclerosis (the CLARITY study), oral cladribine at 96 weeks significantly reduced annual relapse ra...
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ژورنال
عنوان ژورنال: Clinical Pharmacokinetics
سال: 2018
ISSN: 0312-5963,1179-1926
DOI: 10.1007/s40262-018-0695-9