The Cerebral Cortex Overlying Periventricular Leukomalacia: Analysis of Pyramidal Neurons
نویسندگان
چکیده
منابع مشابه
Oxidative injury in the cerebral cortex and subplate neurons in periventricular leukomalacia.
We previously identified immunocytochemical evidence of nitrative and oxidative injury in premyelinating oligodendrocytes in periventricular leukomalacia (PVL). Here, we tested the hypothesis that free radical injury occurs in the overlying cerebral cortex and subplate neurons in PVL. We immunostained for nitrotyrosine, malondialdehyde, and hydroxynonenal adducts and scored neuron staining dens...
متن کاملCerebral visual impairment in periventricular leukomalacia: MR correlation.
PURPOSE To evaluate the involvement of central visual pathways in cases of periventricular leukomalacia, and to correlate the neuroradiologic findings with the degree of visual acuity. METHODS The MR brain examinations of 27 preterm children affected by cerebral palsy resulting from periventricular leukomalacia and without significant ophthalmologic lesions were reviewed retrospectively to se...
متن کاملAnimal Models of Periventricular Leukomalacia
Periventricular leukomalacia, specifically characterized as white matter injury, in neonates is strongly associated with the damage of pre-myelinating oligodendrocytes. Clinical data suggest that hypoxia-ischemia during delivery and intrauterine or neonatal infection-inflammation are important factors in the etiology of periventricular leukomalacia including cerebral palsy, a serious case exhib...
متن کاملMouse Models of Periventricular Leukomalacia
We describe a protocol for establishing mouse models of periventricular leukomalacia (PVL). PVL is the predominant form of brain injury in premature infants and the most common antecedent of cerebral palsy. PVL is characterized by periventricular white matter damage with prominent oligodendroglial injury. Hypoxia/ischemia with or without systemic infection/inflammation are the primary causes of...
متن کاملDopamine synaptic complex with pyramidal neurons in primate cerebral cortex.
Dopamine (DA)-containing projections to the cerebral cortex are considered to play an important role in cognitive processes. Using a recently developed monoclonal antiserum directed against DA and an antibody directed against tyrosine hydroxylase in combination with Golgi impregnation and electron microscopy, we have observed that DA and tyrosine hydroxylase afferents establish symmetric membra...
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ژورنال
عنوان ژورنال: Brain Pathology
سال: 2010
ISSN: 1015-6305,1750-3639
DOI: 10.1111/j.1750-3639.2010.00380.x