منابع مشابه
Resveratrol Suppresses Cardiac Renin Angiotensin System in the Late Phase of Left Ventricular Hypertrophy
Background and objectives: Resveratrol(3,5,4′-trihydroxy-trans-stilbene) is a natural polyphenole phytoalexin which exerts potential cardioprotective effects, but the cellular and molecular mechanisms responsible for these effects are still unknown. Cardiac renin angiotensin system (RAS) over-activation plays an important role in pathogenesis of left ventricula...
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Unilateral ureteral obstruction (UUO) is a clinical scenario that leads to obstructive nephropathy. UUO alters the expression of many mediators in the ipsilateral kidney. Renin-angiotensin system (RAS) is involved in UUO. Angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7) as the main arms of RAS influence kidney function which may alter by UUO. Ang II via Ang II receptor subtypes I (AT1R) ...
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The heart develops left ventricular hypertrophy (LVH) in response to increased afterload in order to compensate for its wall stress and to maintain normal cardiac function.' Although the development of cardiac hypertrophy is itself an adaptive phenomenon, it is an important cause of increased morbidity and mortality.2 Thus cardiac hypertrophy has recently attracted attention as an important ris...
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Major complications associated with cardiac surgery are still common and carry great prognostic significance. β-Blockers, statins, antiplatelets, and renin-angiotensin system (RAS) blockers are current medical interventions to prevent cardiovascular complications in cardiac surgery. Renin-angiotensin system blockers include angiotensin-converting enzyme inhibitors, angiotensin II receptor block...
متن کاملThe renin-angiotensin-aldosterone system and the cardiac natriuretic peptides.
Natriuretic peptides and the reninangiotensin-aldosterone system (RAAS) have reciprocal effects at multiple sites and in varied situations. They interact in health and cardiovascular disease to influence renal, endocrine, and haemodynamic function and cardiovascular cell growth. The atrial natriuretic peptide (atrial natriuretic factor, ANF) discovered by De Bold in 19811 was cloned and sequenc...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1999
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.85.7.643