منابع مشابه
The carboxy-terminal domain initiates trimerization of bacteriophage T4 fibritin.
Bacteriophage T4 fibritin is a triple-stranded, parallel, segmented alpha-helical coiled-coil protein. Earlier we showed that the C-terminal globular domain (foldon) of fibritin is essential for correct trimerization and folding of the protein. We constructed the chimerical fusion protein W31 in which the fibritin foldon sequence is followed by the small globular non-alpha-helical protein gp31 ...
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Regulated exocytosis requires tight coupling of the membrane fusion machinery to a triggering signal and a fast response time. Complexins are part of this regulation and, together with synaptotagmins, control calcium-dependent exocytosis. Stimulatory and inhibitory functions have been reported for complexins. To test if complexins directly affect membrane fusion, we analyzed the 4 known mammali...
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RNA helicases are essential for virtually all cellular processes, however, their regulation is poorly understood. The activities of eight RNA helicases are required for pre-mRNA splicing. Amongst these, Brr2p is unusual in having two helicase modules, of which only the amino-terminal helicase domain appears to be catalytically active. Using genetic and biochemical approaches, we investigated in...
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Cardiac function depends fundamentally on gap junctions, plaques of transmembrane channels constructed from connexin proteins that bridge the plasma membranes of adjacent myocytes. By electrically coupling the entire myocyte population of the heart, these junctions preside over the cell-to-cell passage of the precisely orchestrated patterns of current flow that synchronize, coordinate, and harn...
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It has recently been shown that a class of secreted proteins — the Dickkopfs — are released by the Spemann organizer of Xenopus and are potent antagonists of Wnt signaling [1]. Although it has been reported that the Dickkopf (Dkk) proteins contain two cysteine-rich domains, no direct functional or structural conclusions have been drawn from their sequences. The role of Wnt signaling in animal d...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2007
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.107.165662