THE CARBON MONOXIDE DONOR, TOPIRAMATE, AND BLOCKERS OF AQUAPORINE RECEPTORS DECREASE MYOCARDIAL ISCHEMIA-REPERFUSION INJIRY

We investigated the metabolism of mouse isolated heart under influence tricarbonyldichlorothenium (II)- dimer (CORM-2 and 2,3-4,5-bis-O-isopropylidene-βD-fructopyranose sulfamate (topiramate) as potential blockers aquaporine channel (AQP3) cardiac myocytes. The results were compared with those obtained from group receiving anti-AQP3 monoclonal antibodies. A decrease in coronary flow was found during period preceding ischemia (topiramate did not cause this effect). However, at end reperfusion, CORM-2 responsible for its stabilization. This compound affect glucose intake increased it only reperfusion), decreased Ca2+ deposition muscle (AQP3-IgG antibodies topiramate had similar effect), creatinine release, AST (especially reperfusion). action amplitude R waveform before reperfusion. At reperfusion R-wave decreased. effect caused an increase beginning Administration CORM-2, resulted prolongation interval ischemia. same time, these drugs reduced development ischemic damage. indicate that released CO has effects to signs calcium blocking.