The canine model to test functional tissue-engineered cartilage

The Tissue Engineered Approaches for Cartilage Repair

Technological improvements in biology, medicine, chemistry, engineering and material science have allowed deeper insights into the architectural and molecular organization levels of tissues and materials, providing innovative approaches and tools for medical treatments. One of the therapeutic targets that may benefit from these new issues is damaged human articular cartilage, a tissue unable to...

Modeling the development of tissue engineered cartilage

A finite-element approach was formulated, aimed at enabling an integrated study of mechanical and biochemical factors that control the functional development of tissue engineered constructs. A nonlinear biphasic displacement-velocity-pressure description was combined with advective and diffusive solute transport, uptake and biosynthesis. To illustrate the approach we focused on the synthesis an...

Construction of functional tissue-engineered bone using cell sheet technology in a canine model

The aim of the present study was to construct functional tissue-engineered bone with cell sheet technology and compare the efficacy of this method with that of traditional bone tissue engineering techniques. Canine bone mesenchymal stem cells (BMSCs) were isolated using density gradient centrifugation and then cultured. The BMSCs were induced to differentiate into osteoblasts and cultured in te...

Decellularized Cartilage as a Scaffold for Tissue Engineered Cartilage

Tissue Engineered Cartilage Patches for Laryngotracheal Reconstruction

Galway, Ireland Tissue Engineered Cartilage Patches for Laryngotracheal Reconstruction James E. Dennis, David Gilpin, Mark Weidenbecher, Corresponding Author: [email protected] Case Western Reserve University, Cleveland, OH, USA and University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH USA Introduction Currently, the treatment for tracheal stenosis in infants is ...