The C677T mutation in the methylene tetrahydrofolate reductase gene increases serum uric acid in elderly men
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چکیده
منابع مشابه
The C677 Mutation in Methylene Tetrahydrofolate Reductase Gene: Correlation with Uric Acid and Cardiovascular Risk Factors in Elderly Korean men
The C677T mutation in the methylene tetrahydrofolate reductase (MTHFR) gene results in elevated homocysteine levels and, presumably, in increased cardiovascular risk. Moreover, elevated homocysteine levels are reportedly associated with high serum uric acid levels. We evaluated the MTHFR genotype and a panel of biochemical, hematological variables, and lifestyle characteristics in 327 elderly K...
متن کاملAssociation between the methylene tetrahydrofolate reductase gene C677T mutation and colchicine unresponsiveness in Behcet’s disease
PURPOSE Behcet's disease (BD) is a multisystemic immunoinflammatory disorder characterized by mucocutaneous, ocular, vascular, and central nervous system manifestations. The common methylene tetrahydrofolate reductase (MTHFR) gene C677T mutation is a known risk factor for thrombosis. The aim of this study was to investigate the MTHFR gene C677 mutation in patients with BD and evaluate if there ...
متن کامل[Mutations in the methylene-tetrahydrofolate reductase gene and Down syndrome].
Down syndrome (DS) is a complex genetic and metabolic disorder attributed to the presence of three copies of chromosome 21. The extra chromosome derives from the mother in 93% of cases and is due to abnormal chromosome segregation during meiosis (nondisjunction). Except for advanced age at conception, maternal risk factors for meiotic nondisjunction are not well established. A recent preliminar...
متن کامل5,10-methylene tetrahydrofolate reductase C677T gene polymorphism, homocysteine concentration and the extent of premature coronary artery disease in southern Iran
Elevated level of plasma homocysteine (Hcy) has been identified as an independent risk factor for coronary artery disease (CAD). Furthermore, numerous studies have documented the influences of a common polymorphism (C677T) of methylenetetrahydrofolate reductase (MTHFR) on homocysteine levels. However the relationship between this mutation and cardiovascular diseases (CVD) has remained as a cont...
متن کاملThe Methylene Tetrahydrofolate Reductase Gene Variant C677T is not Associated with Migraine in Twelve Sudanese Pedigrees with Migraine
No definitive pathophysiology exists for migraine yet, nevertheless, many theories were postulated with the most ancient one being the vascular theory which was developed by H. Wolff during the 1940s [1]. According to Lauritzen, Wolff described migraine as a vasospastic disorder that is initiated by vasoconstriction in the cranial vasculature. The vasoconstriction is then followed by dilatation...
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ژورنال
عنوان ژورنال: Journal of Human Genetics
سال: 2000
ISSN: 1434-5161,1435-232X
DOI: 10.1007/s100380070037