The Brugada syndrome: diagnostic criteria and cellular mechanisms
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چکیده
منابع مشابه
The Brugada syndrome: diagnostic criteria and cellular mechanisms.
collaboration is needed to identify the population most likely to respond favourably to a training programme in order to permit efficient resource utilization. The results of the Harrington paper suggest that the greatest benefit would be observed in deconditioned, well-motivated patients with symptomatic heart failure. This potential treatment deserves to be explored further. Our traditional f...
متن کاملProposed diagnostic criteria for the Brugada syndrome.
Asyndrome characterized by ST-segment elevation in right precordial leads (V1 to V3) that is unrelated to ischemia, electrolyte disturbances, or obvious structural heart disease was reported as early as 1953,1 but was first described as a distinct clinical entity associated with a high risk of sudden cardiac death in 1992.2–4 The Brugada syndrome is a familial disease that displays an autosomal...
متن کاملProposed diagnostic criteria for the Brugada syndrome: consensus report.
Brugada, Pedro Brugada, Domenico Corrado, Richard N.W. Hauer, Robert S. Kass, Arthur A.M. Wilde, Charles Antzelevitch, Martin Borggrefe, Josep Brugada, Ramón Proposed Diagnostic Criteria for the Brugada Syndrome : Consensus Report ISSN: 1524-4539 Copyright © 2002 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online 72514 Circulation is published by the American Heart A...
متن کامل[Diagnostic criteria for the Brugada syndrome: can they be improved?].
INTRODUCTION Diagnosis of Brugada syndrome (BS) currently requires documentation of a characteristic repolarization pattern (type 1 Brugada ECG). Mutations in the SCN5A gene, which codes for sodium channel Na(v) 1.5, are found in 38% of familial cases of BS. Sodium current dysfunction negatively affects the cardiac fast response action potential, particularly in atrial and ventricular myocytes ...
متن کاملCellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation.
BACKGROUND The Brugada syndrome is characterized by marked ST-segment elevation in the right precordial ECG leads and is associated with a high incidence of sudden and unexpected arrhythmic death. Our study examines the cellular basis for this syndrome. METHODS AND RESULTS Using arterially perfused wedges of canine right ventricle (RV), we simultaneously recorded transmembrane action potentia...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2001
ISSN: 0195-668X
DOI: 10.1053/euhj.2000.2461