The blood biomarkers puzzle – A review of protein biomarkers in neurodegenerative diseases

Neurodegenerative diseases are heterogeneous in their cause and clinical presentation making assessment disease monitoring challenging. Because of this, there is an urgent need for objective tools such as fluid biomarkers able to quantitate different aspects the disease. In last decade, technological improvements awareness importance biorepositories led discovery evolving number covering main characteristics neurodegenerative neurodegeneration, protein aggregates inflammation. The ability each aspect at a high definition enables more precise stratification patients inclusion trials, hence reducing noise that may hamper detection therapeutical efficacy allowing smaller but likewise powered studies, which particularly improves start trials rare neurological diseases. Moreover, use has potential support targeted intervention, it now emerging treatment amyloid-beta deposition suffering from Alzheimer’s Here we review knowledge evolved measurement biomarker proteins conditions.