منابع مشابه
The biology of interleukin-6.
B CELLS ARE the only eukaryotic cells that are able to produce antibody molecules. Their growth and differentiation into antibody producing cells require the presence of T cells and macrophages; the function of these cells was found to be replaced by soluble factors. 3 In the early i980s it was shown that at least two different kinds of factors were required in the regulation of B cell response...
متن کاملThe biology and medical implications of interleukin-6.
Cytokines are soluble mediators, which aid cell-to-cell communication in immune responses, and interleukin-6 (IL-6) is a prototypical cytokine featuring redundant and pleiotropic activity. The complete elucidation of the IL-6-mediated signal transduction system has provided a molecular basis for the characteristic features of cytokines. When tissue damage or inflammation due to infections or in...
متن کاملThe Value of Interleukin-8 and Interleukin-6 in Cervical Secretions as Predictors of Preterm Delivery
Background and Objective: Preterm birth occurs in 8% to 11% of all pregnancies and is responsible for 75% to 80% of all neonatal deaths. Cytokines may be involved in the etiology of preterm birth through their stimulation of prostaglandin synthesis. Cytokines may be released intocervicovaginal fluid during the breakdown of the chorio-decidual adhesion or from an inflammatory reactio...
متن کاملMolecular and cellular biology of interleukin-6 and its receptor.
Interleukin-6 (IL-6) is a member of the family of cytokines collectively termed "the interleukin-6 type cytokines." Among its many functions, IL-6 plays an active role in immunology, bone metabolism, reproduction, arthritis, neoplasia, and aging. IL-6 expression is regulated by a variety of factors, including steroidal hormones, at both the transcriptional and post-transcriptional levels. IL-6 ...
متن کاملInterleukin-6: Biology, signaling and strategies of blockade.
Interleukin-6 (IL-6) is one of the most important inflammatory cytokines. IL-6 is unique in signaling via a membrane bound and a soluble receptor. Intriguingly, these two pathways strongly differ in their biologic consequences. While classic IL-6 signaling via the membrane bound receptor is mainly regenerative and protective, IL-6 trans-signaling via the soluble IL-6R is rather pro-inflammatory...
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ژورنال
عنوان ژورنال: Blood
سال: 1989
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v74.1.1.bloodjournal7411