The bacterial transcription repair coupling factor
نویسندگان
چکیده
منابع مشابه
An N-terminal clamp restrains the motor domains of the bacterial transcription-repair coupling factor Mfd
Motor proteins that translocate on nucleic acids are key players in gene expression and maintenance. While the function of these proteins is diverse, they are driven by highly conserved core motor domains. In transcription-coupled DNA repair, motor activity serves to remove RNA polymerase stalled on damaged DNA, making the lesion accessible for repair. Structural and biochemical data on the bac...
متن کاملStructural basis for the bacterial transcription-repair coupling factor/RNA polymerase interaction
The transcription-repair coupling factor (TRCF, the product of the mfd gene) is a widely conserved bacterial protein that mediates transcription-coupled DNA repair. TRCF uses its ATP-dependent DNA translocase activity to remove transcription complexes stalled at sites of DNA damage, and stimulates repair by recruiting components of the nucleotide excision repair pathway to the site. A protein/p...
متن کاملStructural and biochemical analysis of the UvrA-binding module of the bacterial transcription-repair coupling factor Mfd
Diese Dissertation wurde selbständig, ohne unerlaubte Hilfe erarbeitet. Structural basis for transcription coupled repair: the N-terminus of Mfd resembles UvrB with degenerate ATPase motifs. Journal of Molecular Biology 355(4): 675-683. "[One] topic we touched on was mutation ... We totally missed the possible role of … [DNA] repair although … I later came to realise that DNA is so precious tha...
متن کاملTranscription-repair coupling and mutation frequency decline.
Mutation frequency decline (MFD) is the rapid and irreversible decrease in the frequency of certain damage-induced mutations that occurs in Escherichia coli when protein synthesis is transiently inhibited immediately after the damaging treatment (49). Transcription-repair coupling (TRC) is the preferential repair of transcribed regions at a faster rate compared to the rest of the genome (5). Th...
متن کاملATP-dependent chromatin remodeling by the Cockayne syndrome B DNA repair-transcription-coupling factor.
The Cockayne syndrome B protein (CSB) is required for coupling DNA excision repair to transcription in a process known as transcription-coupled repair (TCR). Cockayne syndrome patients show UV sensitivity and severe neurodevelopmental abnormalities. CSB is a DNA-dependent ATPase of the SWI2/SNF2 family. SWI2/SNF2-like proteins are implicated in chromatin remodeling during transcription. Since c...
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ژورنال
عنوان ژورنال: Current Opinion in Structural Biology
سال: 2007
ISSN: 0959-440X
DOI: 10.1016/j.sbi.2007.01.005