The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains.
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چکیده
منابع مشابه
The pituitary-specific regulatory gene GHF1 contains a minimal cell type-specific promoter centered around its TATA box.
GHF-1 is a pituitary-specific transcription factor responsible for activation of the growth hormone (GH) gene. The GHF1 gene is expressed exclusively in cells of the somatotrophic lineage, and its transcription is extinguished in somatic cell hybrids. The minimal sequences required for differential transcription of GHF1 in GH-expressing and -nonexpressing cell lines and somatic cell hybrids wer...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
The oct-1 homeo domain contacts only part of the octamer sequence and full oct-1 DNA-binding activity requires the POU-specific domain.
The ubiquitous octamer-binding protein oct-1 contains a POU domain required for DNA binding, which can be subdivided into a POU-specific domain and a POU homeo domain. We have overproduced the POU domain and the POU homeo domain in a vaccinia expression system, purified both polypeptides to near homogeneity, and compared their DNA-binding properties. In contrast to the POU domain, the homeo dom...
متن کاملStage- and tissue-specific expression of two homeo box genes in sea urchin embryos and adults.
We report the isolation of two different homeo box genes, HB3 and HB4, from the Hawaiian sea urchin Tripneustes gratilla. DNA sequencing revealed a definitive Antennapedia (Antp) class homeo box in each gene. Southern transfer hybridizations showed the genes to be single-copy. A 5.7-kb transcript of the HB3 gene was found in ovary, testis, small intestine and gastrula poly(A)+ RNA. The HB4 gene...
متن کاملNovel murine homeo box gene on chromosome 1 expressed in specific hematopoietic lineages and during embryogenesis.
We describe here a new murine homeo box gene, denoted Hlx, which is expressed within specific hematopoietic lineages. The cDNA sequence indicates that Hlx differs markedly from known vertebrate homeo box genes, and linkage analysis of an interspecific murine backcross showed that it resides at a novel homeo box locus on the distal portion of mouse chromosome 1. The Hlx homeo domain is most simi...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 1988
ISSN: 0890-9369
DOI: 10.1101/gad.2.12a.1570