منابع مشابه
The excitement of discovery.
I had the good luck to start research at the dawn of molecular biology when it was possible to ask fundamental questions about the nature of the nucleic acids and how information is transferred in living systems. The search for answers led me into many different areas, often with the question of how molecular structure leads to biological function. Early work in this period provided some of the...
متن کاملMountain excitement
theory? What is its legacy today in biology? Quite a few mathematical fads have burst onto the popular press, promising great new insights into biology: information theory, catastrophe theory, chaos theory, and most recently complexity theory, to name just a few. All were quite useful in their founding fields (except complexity, which has proven slippery to even define), but all failed to live ...
متن کاملThe chlorpropamide alcohol flush.
Many non-insulin dependent diabetics (NIDDs) on the sulphonylurea chlorpropamide experience intense facial flushing after taking alcohol even in small amounts. This chlorpropamide alcohol flush (CPAF) was first recognized within months of the introduction of the drug in the 1950s [ l ] but, although an alcohol flush occasionally occurs with tolbutamide [ 2 , 31, it has not been reported with ot...
متن کاملRFLUSH: Rethink the Flush
A FLUSH command has been used for decades to enforce persistence and ordering of updates in a storage device. The command forces all the data in the volatile buffer of the storage device to non-volatile media to achieve persistency. This lump-sum approach to flushing has two performance consequences. First, it slows down nonvolatile materialization of the writes that actually need to be made du...
متن کاملCalming the excitement in ALS.
The concept of excitotoxicity, first established by the pioneering work of John Olney, traditionally has been applied to lesions of the CNS, focusing mostly on glutamate as a neurotoxic excitatory amino acid neurotransmitter. Indeed, glutamate excitotoxicity remains one of the best-supported theories for motor neuron death in amyotrophic lateral sclerosis (ALS), and was the pharmacologic inspir...
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ژورنال
عنوان ژورنال: Nature
سال: 1879
ISSN: 0028-0836,1476-4687
DOI: 10.1038/020121a0