The Attraction between Homologous Chromosomes
نویسندگان
چکیده
منابع مشابه
Recombination Between Existing Homologous Chromosomes
Enchanced survival of ultraviolet-irradiated Escherichia coli dependent upon the recA + gene appears to result from the ability to seal gaps in newly synthesized deoxyribonucleic acid (DNA) produced when DNA containing pyrimidine dimers is replicated (8). Strains which are recombination-deficient (recA) do not seal these gaps and degrade their DNA to a considerable extent. Rupp and Howard-Fland...
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The organization of chromosomes is important for various biological processes and is involved in the formation of rearrangements often observed in cancer. In mammals, chromosomes are organized in territories that are radially positioned in the nucleus. However, it remains unclear whether chromosomes are organized relative to each other. Here, we examine the nuclear arrangement of 10 chromosomes...
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Telomeres are important structures for DNA replication and chromosome stability during cell growth. Telomere length has been correlated with the division potential of human cells and has been found to decrease with age in healthy individuals. Nevertheless, telomere lengths within the same cell are heterogeneous and certain chromosome arms typically have either short or long telomeres. Both the ...
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Homologous recombination (HR) between parental chromosomes occurs stochastically. Here, we report on targeted recombination between homologous chromosomes upon somatic induction of DNA double-strand breaks (DSBs) via CRISPR-Cas9. We demonstrate this via a visual and molecular assay whereby DSB induction between two alleles carrying different mutations in the PHYTOENE SYNTHASE (PSY1) gene result...
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We have observed genetic recombination between ura3( -) mutations (among them extensive deletions) carried on "episomal" (i.e., 2micro DNA-containing) plasmids and other ura3( -) alleles present at the normal chromosomal URA3 locus. The recombination frequency found was comparable to the level observed for classical mitotic recombination but was relatively insensitive to sunlamp radiation, whic...
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ژورنال
عنوان ژورنال: Nature
سال: 1925
ISSN: 0028-0836,1476-4687
DOI: 10.1038/116244c0