The Association of Upper Body Obesity with Insulin Resistance in the Newfoundland Population

Body-fat distribution is a primary risk factor for insulin resistance and cardiovascular disease. Visceral fat explains only portion of this risk. The link between upper-body uncertain. Furthermore, not clearly defined. Dual-energy X-ray absorptiometry (DXA) can accurately quantify body fat. In study, we explored the relationship non-visceral adiposity other markers metabolic syndrome. Fat proportions in upper body, leg, visceral regions were quantified by using DXA 2547 adult Newfoundlanders aged 19 older. Adjusting remaining regions, performed partial correlation analysis each region defined Homeostatic Model Assessment (HOMA). Similarly, was also syndrome, including high-density lipoprotein cholesterol (HDL), triglycerides (TG), mass index (BMI), blood pressure. Major confounding factors, age, caloric intake, physical activity, statistically controlled analysis. Interactions sex, menopausal status, medication status tested. Arm correlated with HOMA-IR (R = 0.132, p < 0.001) HOMA-β 0.134, 0.001). 0.230, 0.160, No significant trunk found. Non-visceral negatively HDL men −0.110, women −0.117, TG (total: R 0.079, 0.001; men: 0.105, 0.012; women: 0.078, women, leg −0.196, −0.101, 0.012). Upper-body arms an independent contributor to resistance. Leg protective against syndrome women.