The association between MDR1 C3435T genetic polymorphism and the risk of multidrug-resistant epilepsy in Egyptian children

Abstract Background Epilepsy is a chronic disease affecting about 2% of the population and considered serious neurological disease. Despite its good prognosis, 20–30% epileptic patients were not cured their seizures even with many trials antiepileptic drug (AED) therapy. The resistance mechanism still unclear, maybe due to effect genetic factors on bioavailability drugs. Consequently, association between therapy presence gene called “multidrug 1 ( MDR1 )” had been proposed. Thus, present study aimed understand relationship polymorphism C3435T AEDs. Result A non-significant was found single-nucleotide (SNP) drug-resistant epilepsy. However, there statistical significance in type genotype distribution, cases that maintained sodium valproate genotype. Conclusion Possible involvement C 3435T clarifies importance variability response may help find novel for epilepsy, by targeting biological mechanisms responsible epilepsy each specific individual. Future studies bigger sample sizes other racial populations will be necessary.