The association between βeta 2-microglobulin and bronchopulmonary dysplasia

Abstract Objective Previous studies showed that increased urinary Beta 2-microglobulin (β2-M) level is associated with fetal inflammatory response and successfully predict bronchopulmonary dysplasia (BPD). We aimed to investigate the clinical utility of serum β2-M levels BPD in preterm infants. Method Infants born between May November 2018 whose gestational age (GA) was <32 weeks were included into study. During routine blood work first couple hours life an extra 0.5 mL drawn study later on. compared infants who developed or not. Results Data analysis 111 performed. Out infants, 37 died before diagnosis out rest 74 38 (34.2%) diagnosed BPD. Mean GA 28 ± 1.8 29.9 1.4 ( p < 0.01) mean birth weights (BW) 1,086 316 1,395 348 g group without respectively. Demographic characteristics two groups similar. While white cell count, CRP IL-6 similar both groups, significantly higher (4.84 1.0 3.79 0.95 mg/L, = 0.01). Furthermore a weak correlation observed r 0.23, 0.04). Conclusion Serum which obtained early postnatal could developing Monitoring have high risk factors for development may provide additional benefit predicting