The association between catechol-O-methyl-transferase Val108/158Met polymorphism and suicide
نویسندگان
چکیده
منابع مشابه
association of catechol-o-methyl transferase gene polymorphism with prostate cancer and benign prostatic hyperplasia
background : a single nucleotide variation within atechol-o-methyl transferase (comt) gene may alter the comt enzyme activity level. polymorphism of val158met in the comt gene has been related to malignancy. in this regard, a study was carried out to find a possible association between the comt gene polymorphism in patients with sporadic prostate cancer (pca) and benign prostatic hyperplasia (...
متن کاملAssociation of catechol-o-methyl transferase gene polymorphism with prostate cancer and benign prostatic hyperplasia
BACKGROUND A single nucleotide variation within catechol-o-methyl transferase (COMT) gene may alter the COMT enzyme activity level. Polymorphism of Val158Met in the COMT gene has been related to malignancy. In this regard, a study was carried out to find a possible association between the COMT gene polymorphism in patients with sporadic prostate cancer (PCa) and benign prostatic hyperplasia (BP...
متن کاملCatechol-O-methyl transferase and schizophrenia.
Catechol-O-methyl transferase (COMT) is an enzyme involved in the degradation of dopamine. The most commonly examined polymorphism within the COMT gene is Val108/158Met polymorphism, which results in three to fourfold difference in COMT enzyme activity. It is particularely important in prefrontal cortex, since COMT activity is the most important regulator of the prefrontal dopamine function. Gi...
متن کاملThe lack of association between catechol-O-methyl-transferase Val108/158Met polymorphism and smoking in schizophrenia and alcohol dependence.
Patients with schizophrenia and alcohol dependence are often smokers. There are inconsistencies across the literature on the relationship between the functional catechol-O-methyl-transferase (COMT) Val108/158Met polymorphism and smoking and/or nicotine dependence (Redden et al., 2005; Tammimaki and Mannisto, 2010). The study elucidated the association between the COMT Val108/158Met polymorphism...
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Review articles have focused attention on and cited possible reasons for the nonreplication of genetic association studies. Herein, we illustrate how one might work through these possible reasons to make a judgment about the most plausible reason(s) when faced with two or more studies which yield seemingly inconsistent results. In the first study, 342 treatment-seeking smokers were genotyped fo...
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ژورنال
عنوان ژورنال: Genes, Brain and Behavior
سال: 2011
ISSN: 1601-1848
DOI: 10.1111/j.1601-183x.2011.00695.x