The Assembly Pathway of Mitochondrial Respiratory Chain Complex I
نویسندگان
چکیده
منابع مشابه
The Assembly Pathway of Mitochondrial Respiratory Chain Complex I.
Mitochondrial complex I is the largest integral membrane enzyme of the respiratory chain and consists of 44 different subunits encoded in the mitochondrial and nuclear genome. Its biosynthesis is a highly complicated and multifaceted process involving at least 14 additional assembly factors. How these subunits assemble into a functional complex I and where the assembly factors come into play is...
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Human mitochondrial complex I is the largest enzyme of the respiratory chain and is composed of 44 different subunits. Complex I subunits are encoded by both nuclear and mitochondrial (mt) DNA and their assembly requires a number of additional proteins. FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) was recently identified as a putative assembly factor and FOXRED1 mutations ...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2017
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2016.09.002