The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors
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منابع مشابه
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
2-Arachidonoylglycerol (2-AG) and anandamide are endocannabinoids that activate the cannabinoid receptors CB1 and CB2. Endocannabinoid signaling is terminated by enzymatic hydrolysis, a process that for anandamide is mediated by fatty acid amide hydrolase (FAAH), and for 2-AG is thought to involve monoacylglycerol lipase (MAGL). FAAH inhibitors produce a select subset of the behavioral effects ...
متن کاملThe endocannabinoid 2-arachidonoylglycerol promotes sperm developement through activation of cannabinoid-2 receptors
The exact role of the endocannabinoid system (ECS) during spermatogenesis has not been clarified. Scientists at the University of Rome "Tor Vergata" (Italy) and at the Endocannabinoid Research Group – Consiglio Nazionale delle Ricerche (Pozzuoli, Italy) have used purified germ cell fractions representative of all phases of spermatogenesis and primary cultures of spermatogonia, to demonstrate th...
متن کاملThe serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors
The endocannabinoid 2-arachidonoylglycerol (2-AG) is a lipid mediator involved in various physiological processes. In response to neural activity, 2-AG is synthesized post-synaptically, then activates pre-synaptic cannabinoid CB1 receptors (CB1Rs) in a retrograde manner, resulting in transient and long-lasting reduction of neurotransmitter release. The signalling competence of 2-AG is tightly r...
متن کاملAnandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand.
Two endogenous ligands for cannabinoid receptors, anandamide (arachidonylethanolamide) and 2-arachidonoylglycerol, lose their biological activities by enzymatic hydrolysis. A cDNA for a rat liver enzyme hydrolyzing anandamide as well as oleamide was overexpressed in COS-7 cells. When the particulate fraction was allowed to react with 2-arachidonoylglycerol, arachidonic acid was produced. In con...
متن کامل[Endogenous cannabinoid receptor ligands--anandamide and 2-arachidonoylglycerol].
Marijuana has been used as a traditional medicine and a pleasure-inducing drug for thousands of years around the world, especially in Asia. Delta(9)-tetrahydrocannabinol, major psychoactive component of marijuana, has been shown to interact with specific cannabinoid receptors, thereby eliciting a variety of pharmacological responses in experimental animals and human. In 1990, the gene encoding ...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2012
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.2012.02059.x