The Antinociceptive Effect of Lonchocarpus Araripensis Lectin is Mediated by Endocannabinoid Receptors
نویسندگان
چکیده
The involvement of endocannabinoid receptors in the antinociceptive activity Lonchocarpus araripensis lectin (LAL) was investigated model carragenan-induced hypernociception. Swiss mice received LAL (10 mg/kg) by intravenous (i.v.) route 30 min before subcutaneous (s.c.) injection carrageenan paws. Animals were treated with antagonists CB1 (AM251) or CB2 (AM630) cannabinoid lectin. inhibited hypernociception induced (1 h: 11.87 ± 0.61 g; 3 9.7 0.70 g). AM251 4.75 0.41 4.5 0.53 g) and AM630 5.67 0.56 5 0.68 reversed inhibitory effect LAL. is mediated receptors.
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ژورنال
عنوان ژورنال: International journal of scientific advances
سال: 2021
ISSN: ['2708-7972']
DOI: https://doi.org/10.51542/ijscia.v2i4.21