The antibody response to methyl isocyanate: experimental and clinical findings.

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The antibody response to methyl isocyanate: experimental and clinical findings.

Sera from 99 subjects exposed to the industrial gas leak in Bhopal on December 2, 1984 were studied along with sera from guinea pigs exposed to methyl isocyanate (MIC) to determine the production of antibodies specific to (MIC). Each of the four guinea pigs injected with the reactive isocyanate produced MIC-specific antibodies in titres of 1:5120 to 1:10240, when tested with MIC-guinea pig albu...

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Epidemiological and experimental studies on the effects of methyl isocyanate on the course of pregnancy.

Although press reports indicate that the leakage of methyl isocyanate (MIC) on December 3, 1984, in Bhopal has led to an increase in spontaneous abortions, stillbirths, infant mortality, and fetal abnormalities, no clinical or experimental studies on the reproductive toxicity of MIC were reported in scientific journals for several months after the accident. We therefore conducted, 9 months afte...

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Exposure and response to methyl isocyanate: results of a community based survey in Bhopal.

In the two weeks immediately after the Bhopal disaster a community based survey was carried out in a series of eight exposed and two non-exposed clusters of households. The primary concern was the effect of the gas (subsequently identified as methyl isocyanate) on the eyes of the victims but data were also sought on respiratory status and the first symptoms of the exposure. No case of blindness...

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Methyl isocyanate exposure and atypical lymphocytes.

December 3, 1984 marks one of the deadliest chemical disasters of the world took place in Bhopal. The disaster took a toll of 3600 human lives and scores of pets almost instantly. Additional 200 000 people were exposed to the killer gas—methyl isocyanate and its intermediates—to varying degrees.1 Almost 27 years have gone by since occurrence of this tragic event, the health status of the affect...

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 1987

ISSN: 0091-6765,1552-9924

DOI: 10.1289/ehp.8772169