The angiotensin II type 1 receptor and receptor-associated proteins
نویسندگان
چکیده
منابع مشابه
Angiotensin II type 1 receptor blockers.
In the 1970s, a series of observations demonstrated that angiotensin II has deleterious effects on the heart and kidney and that patients with high levels of plasma renin activity are at a higher risk of developing stroke or myocardial infarction than those with low plasma renin activity.1,2 Thereafter, the development of pharmacological probes that block the renin-angiotensin system helped def...
متن کاملAngiotensin II Type 1 Receptor‐Associated Protein Regulates Kidney Aging and Lifespan Independent of Angiotensin
BACKGROUND The kidney is easily affected by aging-associated changes, including glomerulosclerosis, tubular atrophy, and interstitial fibrosis. Particularly, renal tubulointerstitial fibrosis is a final common pathway in most forms of progressive renal disease. Angiotensin II type 1 receptor (AT1R)-associated protein (ATRAP), which was originally identified as a molecule that binds to AT1R, is ...
متن کاملeffect of angiotensin ii type 1 receptor antagonist, losartan on inflammatory factor in atherosclerotic rabbits
materials and methods: 32 new zealand rabbits were randomly divided into three groups: control group, high-cholesterol group and losartan group. the level of weights, serum lipid levels and inflammatory factors, such as il-6 and hs c-reactive protein were detected before the losartan intervention and two months after the losartan intervention respectively. the content of angii was detected on l...
متن کاملangiotensin ii type 1 receptor gene a1166c polymorphism was not associated with acute coronary syndrome in an iranian population
conclusions the at1r a1166c polymorphism appeared not to be associated with the presence of acs in the population studied. background there are very limited data for iranian populations on the predisposing genetic factors for acute coronary syndrome (acs). results there was no statistical difference in the genotype frequency of patients and healthy subjects with regard to age and gender (p > 0....
متن کاملVersatility of the angiotensin II type 1 receptor.
This issue of Circulation Research includes 3 interesting studies that represent new concepts of AT1 receptor–mediated cell signaling in the cardiovascular system, which is currently of intense interest. The AT1 receptor mediates many important cardiovascular responses, including vasoconstriction, vascular and cardiac remodeling (cell proliferation, hypertrophy, and production of extracellular ...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2001
ISSN: 1001-0602,1748-7838
DOI: 10.1038/sj.cr.7290083