The Amyloid Precursor Protein—A Novel Player within the Molecular Array of Presynaptic Nanomachines
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چکیده
منابع مشابه
The Amyloid Precursor Protein—A Novel Player within the Molecular Array of Presynaptic Nanomachines
More than 20 years ago the amyloid precursor protein (APP) was identified as the precursor protein of the Aβ peptide, the main component of senile plaques in brains affected by Alzheimer's disease (AD). The pathophysiology of AD, characterized by a massive loss of synapses, cognitive decline, and behavioral changes was in principle attributed to the accumulation of Aβ. Within the last decades, ...
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The amyloid precursor protein (APP) was discovered in the 1980s as the precursor protein of the amyloid A4 peptide. The amyloid A4 peptide, also known as A-beta (Aβ), is the main constituent of senile plaques implicated in Alzheimer's disease (AD). In association with the amyloid deposits, increasing impairments in learning and memory as well as the degeneration of neurons especially in the hip...
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ژورنال
عنوان ژورنال: Frontiers in Synaptic Neuroscience
سال: 2016
ISSN: 1663-3563
DOI: 10.3389/fnsyn.2015.00021