The alpha2u-globulin discussion.
نویسندگان
چکیده
منابع مشابه
Doubting nongenotoxic mechanisms of renal cancer: comparing apples and oranges in the alpha2u-globulin hypothesis.
Doubting accepted mechanisms in biology is not wrong per se, especially as the contrary would be the death blow to any form of advancement in research; however, doubting without good reason will consume precious energy and resources that could be spent on more fruitful and certainly more pressing matters in biological research. Contrary to good judgment, it appears that some individuals believe...
متن کاملIdentification of alpha2u-globulin and bound volatiles in the Indian common house rat (Rattus rattus).
The alpha2u-globulin (alpha2u) is a pheromone carrier urinary protein believed to be relevant for sexual communication among rats and is characterized in laboratory rats. In the present study 17 kDa protein and the bound pheromones were characterized in a population of wild-type Indian common house rat (Rattus rattus). The protein was purified by two runs of Sephadex G-50 chromatography and ana...
متن کاملThe role of alpha2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats.
The mycotoxin ochratoxin A (OTA) was shown to be a potent kidney carcinogen in rats demonstrating a marked sex difference in the response. Compared to female rats, male rats had a 10-fold higher incidence of kidney carcinomas. The objective of this study was to investigate whether this sex difference in tumor response is due to an exacerbation of effect resulting from the interaction of the mal...
متن کاملWeight of evidence versus weight of speculation to evaluate the alpha2u-globulin hypothesis.
whereas the severity of spontaneous chronic nephropathy in treated male rats relative to controls increased from 52 and 104 weeks. As a result of the current discussion in the literature (3), the kidney specimens were reanalyzed for the hallmarks of x2u-globulin nephropathy sequelae, namely the presence of granular casts and linear mineralization (8). These changes were not observed in male rat...
متن کاملalpha2u-Globulin nephropathy and ravens: do ravens of a different feather flock together?
differentiate significant and trivial chemical hazards and to assess likely risks to humans. This latter justification can be illustrated by the following statement: if all chemicals that are mutagenic in vitro were mutagenic and carcinogenic to humans, and if all rodent carcinogens posed an equal carcinogenic hazard to humans, then there would be no role for mechanistic studies. The fact that ...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1998
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.106-1533049