The African Lymphoma (Burkitt Tumour): Survivals Exceeding Two Years

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Denis Burkitt and the African lymphoma

Burkitt lymphoma has provided a model for the understanding of the epidemiology, the molecular abnormalities that induce tumours, and the treatment of other lymphomas. It is important to remember that the early phases of this work were conducted in Africa where today, unfortunately, the disease usually results in death because of limited resources, even though most children in more developed co...

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Cytogenetic studies in non-African Burkitt lymphoma.

A particular translocation between chromosomes 8 and 14 has been found repeatedly in cytogenetic studies of Burkitt lymphoma, both of African and non-African origin. We report here our findings in cytogenetic studies of direct tumor preparations from 18 non-African Burkitt lymphoma patients, 9 of whom also had cell lines available for study. A t(8;14) was found in direct tumor material in 10 of...

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Non-African Burkitt lymphoma presenting as dysphagia.

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Structure and diversification of immunoglobulin genes in African Burkitt lymphoma.

The article by Lombardo and colleagues described high throughput sequencing of the immunoglobulin (Ig) heavy and light chain genes from African Burkitt lymphomas (BLs). On the basis of their analysis and, in particular, because of the frequent lack of detection of Ig DHJH or VHDHJH rearrangements on the nonexpressed Ig heavy (IgH) chain allele, as well as ongoing mutation on the nonexpressed al...

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Burkitt lymphoma in Uganda: 50 years of ongoing discovery.

W hile working in Uganda, a physician by the name of Denison Parson Burkitt first described the tumor that now carries his name. In 1957, Dr. Burkitt, along with his colleagues, examined a child with what appeared to be swelling along the jaw. After observing a second child with the same clinical presentation, his curiosity prompted him to study hospital records for similar cases. He found that...

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ژورنال

عنوان ژورنال: British Journal of Cancer

سال: 1965

ISSN: 0007-0920,1532-1827

DOI: 10.1038/bjc.1965.10