The addition of olanzapine to valproate or lithium for acute manic or mixed bipolar episodes reduced manic symptoms
نویسندگان
چکیده
منابع مشابه
The addition of olanzapine to valproate or lithium for acute manic or mixed bipolar episodes reduced manic symptoms.
Patients 344 patients (mean age 41 y, 52% women) who had bipolar disorder, manic (48%) or mixed (52%) episodes with or without psychotic episodes; had a score >16 (mean score 22) on the Young Mania Rating Scale (YMRS) at baseline; and had received treatment with a therapeutic blood concentration of lithium (0.6–1.2 mmol/l) or valproate (50–125 ìg/ml) for >2 weeks before visit 1. Follow up was 97%.
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BACKGROUND Severe and persistent mental illnesses in children and adolescents, such as early- onset schizophrenia spectrum (EOSS) disorders and pediatric bipolar disorder (pedBP), are increasingly recognized. Few treatments have demonstrated efficacy in rigorous clinical trials. Enduring response to current medications appears limited. Recently, olanzapine was approved for the treatment of adol...
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BACKGROUND Sub-syndromal symptoms in bipolar disorder impair functioning and diminish quality of life. AIMS To examine factors associated with time spent with sub-syndromal symptoms and to characterise how these symptoms influence outcomes. METHOD In a double-blind randomised maintenance trial, patients received either olanzapine or lithium monotherapy for 1 year. Stepwise logistic regressi...
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Background Bipolar disorder is associated with an increased risk of aggression. However, effective management of hostility and/or agitation symptoms may prevent patients from becoming violent. This analysis investigated the efficacy of the antipsychotic asenapine on hostility and agitation in patients with bipolar I disorder. Methods Data were pooled from three randomized, double-blind, place...
متن کاملEfficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy.
BACKGROUND A 6-week double-blind, randomized, placebo-controlled trial was conducted to determine the efficacy of combined therapy with olanzapine and either valproate or lithium compared with valproate or lithium alone in treating acute manic or mixed bipolar episodes. METHODS The primary objective was to evaluate the efficacy of olanzapine (5-20 mg/d) vs placebo when added to ongoing mood-s...
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ژورنال
عنوان ژورنال: Evidence-Based Mental Health
سال: 2002
ISSN: 1362-0347
DOI: 10.1136/ebmh.5.3.89