The Aconite Alkaloids. XXXV. On Lucidusculine. V

Molecular recognition on supramolecular systems (XXXV)

A novel β-cyclodextrin derivative 4 bearing a pyridinio group on the primary side was synthesized by the reaction of 2-aminopyridine with 6-β-cyclodextrin monoaldehyde 3, and its complexation stability constants with several aliphatic amino acids have been determined in phosphate buffer solution ( pH = 7.2, 0.1 mol L) at 25 by using spectrofluormetric titrations. The stoichiometry is 1 1 for th...

Notes on Some Remedies. XXXV. Oxygen Therapy

The Aconite Alkaloids Ix. the Isolation of Two New Alkaloids from Aconitum Heterophyllum, Heteratisine and Hetisine by Walter A. Jacobs and Lyman C. Craig

In the course of the isolation of atisine from the roots of Aconitum heterophyllum of commercial origin, as presented in Paper VIII (I), it was noted that further concentration of the final mother liquors from atisine hydrochloride yielded a thick solution which on longer standing gave an additional crystalline fraction. It was then found that this fraction (10 gm. from 24 kilos of root) consis...

Experimental Studies on Sodhana of Aconite

Sodhana, a preliminary treatment is known to reduce toxicity, enhance therapeutic merits of drugs and even impart additional pharmacodynamic properties. The present study - Sodhana Aconite, conducted to establish the effect in toxicity chemical changes and comparative pharmacological activity, show definite reduction in the intense cardiotoxic effect in crude Aconite.

Intestinal transport of pure diester-type alkaloids from an aconite extract across the Caco-2 cell monolayer model.

Aconitine (AC), mesaconitine (MA), and hypaconitine (HA) are the active alkaloids identified in aconite tuber, an important traditional Chinese medicine. The study is aimed to investigate their intestinal transport profiles and potential interaction during the intestinal absorption using the Caco-2 cell monolayer model. All three alkaloids had good permeability with P(app) values greater than ...