منابع مشابه
Selection for Unequal Densities of σ70 Promoter-Like Signals in Different Regions of Large Bacterial Genomes
The evolutionary processes operating in the DNA regions that participate in the regulation of gene expression are poorly understood. In Escherichia coli, we have established a sequence pattern that distinguishes regulatory from nonregulatory regions. The density of promoter-like sequences, that could be recognizable by RNA polymerase and may function as potential promoters, is high within regul...
متن کاملAnatomy of Escherichia coli σ70 promoters
Information theory was used to build a promoter model that accounts for the -10, the -35 and the uncertainty of the gap between them on a common scale. Helical face assignment indicated that base -7, rather than -11, of the -10 may be flipping to initiate transcription. We found that the sequence conservation of sigma70 binding sites is 6.5 +/- 0.1 bits. Some promoters lack a -35 region, but ha...
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The apoptotic programme is evolutionarily conserved between yeast and metazoan organisms. We have previously identified a number of mammalian cDNAs capable of suppressing the deleterious effects of Bax expression in yeast. We herein report that one such suppressor, named Tsc22((86)), represents the C-terminal 86 amino acids of the previously characterized leucine zipper (LZ) motif-containing tr...
متن کاملInvestigation of a Zα-like Peptide Motif in Koi Herpesvirus
Koi herpesvirus (KHV) is responsible for high mortality in the common carp, a global food staple of which over 1.5 million metric tons is harvested annually. The objective of this study is to investigate B-DNA interactions with a hypothesized Zα, or Z-DNA binding, domain in the KHV open reading frame 112 (ORF112) peptide motif. Mutations analogous to the Y84A and N62D mutations have been shown ...
متن کاملTwo transcription pause elements underlie a σ70-dependent pause cycle.
The movement of RNA polymerase (RNAP) during transcription elongation is modulated by DNA-encoded elements that cause the elongation complex to pause. One of the best-characterized pause sequences is a binding site for the σ(70) initiation factor that induces pausing at a site near lambdoid phage late-gene promoters. An essential component of this σ(70)-dependent pause is the elemental pause si...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2002
ISSN: 1097-2765
DOI: 10.1016/s1097-2765(02)00438-0