The α2C-adrenoceptor deletion322–325 variant and cold-induced vasoconstriction
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چکیده
منابع مشابه
Lack of α2C-Adrenoceptor Results in Contrasting Phenotypes of Long Bones and Vertebra and Prevents the Thyrotoxicosis-Induced Osteopenia
A series of studies have demonstrated that activation of the sympathetic nervous system (SNS) causes osteopenia via β2-adrenoceptor (β2-AR) signaling. However, in a recent study, we found an unexpected and generalized phenotype of high bone mass in female mice with chronic sympathetic hyperactivity, due to double gene inactivation of adrenoceptors that negatively regulate norepinephrine release...
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Gorman, Mark W., Martin Farias III, Keith N. Richmond, Johnathan D. Tune, and Eric O. Feigl. Role of endothelin in -adrenoceptor coronary vasoconstriction. Am J Physiol Heart Circ Physiol 288: H1937–H1942, 2005. First published December 9, 2004; doi:10.1152/ajpheart.01076.2004.—It has been proposed that -adrenoceptor vasoconstriction in coronary resistance vessels results not from -adrenoceptor...
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BACKGROUND The neurotransmitter norepinephrine has been implicated in psychiatric and neurodegenerative disorders. Examination of synaptic norepinephrine concentrations in the living brain may be possible with positron emission tomography (PET), but has been hampered by the lack of suitable radioligands. METHODS We explored the use of the novel α2C-adrenoceptor antagonist PET tracer [(11)C]OR...
متن کاملAlpha-adrenoceptor blockade prevents exercise-induced vasoconstriction of stenotic coronary arteries.
OBJECTIVES The study aimed to evaluate the role of alpha-adrenergic mechanisms during dynamic exercise in both normal and stenotic coronary arteries. BACKGROUND Paradoxical vasoconstriction of stenotic coronary arteries has been reported during dynamic exercise and may be due to several factors such as alpha-adrenergic drive, a decreased release of nitric oxide, platelet aggregation with rele...
متن کاملTherapeutic Potential of Selectively Targeting the α2C-Adrenoceptor in Cognition, Depression, and Schizophrenia—New Developments and Future Perspective
α2A- and α2C-adrenoceptors (ARs) are the primary α2-AR subtypes involved in central nervous system (CNS) function. These receptors are implicated in the pathophysiology of psychiatric illness, particularly those associated with affective, psychotic, and cognitive symptoms. Indeed, non-selective α2-AR blockade is proposed to contribute toward antidepressant (e.g., mirtazapine) and atypical antip...
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ژورنال
عنوان ژورنال: Clinical Autonomic Research
سال: 2009
ISSN: 0959-9851,1619-1560
DOI: 10.1007/s10286-009-0014-5