منابع مشابه
Epistasis and Shapes of Fitness Landscapes
The relationship between the shape of a fitness landscape and the underlying gene interactions, or epistasis, has been extensively studied in the two-locus case. Gene interactions among multiple loci are usually reduced to two-way interactions. We present a geometric theory of shapes of fitness landscapes for multiple loci. A central concept is the genotope, which is the convex hull of all poss...
متن کاملEpistasis and constraints in fitness landscapes
Genotypic fitness landscapes are constructed by assessing the fitness of all possible combinations of a given number of mutations. In the last years, several experimental fitness landscapes have been completely resolved. As fitness landscapes are high-dimensional, their characterization relies on simple measures of their structure, which can be used as statistics in empirical applications. Here...
متن کاملHigher order epistasis and fitness peaks
We show that higher order epistasis has a substantial impact on evolutionary dynamics by analyzing peaks in the fitness landscapes. There are 193,270,310 fitness graphs, or cube orientations, for 4-locus systems, distributed on 511, 863 isomorphism classes. We identify all fitness graphs with 6 or more peaks. 81 percent of them imply 4-way epistasis, whereas 9 percent of all 4-locus fitness gra...
متن کاملNaturally segregating loci exhibit epistasis for fitness.
The extent to which gene interaction or epistasis contributes to fitness variation within populations remains poorly understood, despite its importance to a myriad of evolutionary questions. Here, we report a multi-year field study estimating fitness of Mimulus guttatus genetic lines in which pairs of naturally segregating loci exist in an otherwise uniform background. An allele at QTL x5b-a lo...
متن کاملThe role of fitness and aerobic exercises on the executive functions of dyslexia and dyscalculia children
Abstract Background and Purpose: Studies carried out in recent decades show that exercises have useful impact on improving executive functions. Therefore, this study aims to investigate the roles of fitness and aerobic exercises on problem-solving process of dyslexic and dyscalculia children. Materials and methods: Using systematic review study and key terms including fitness and aerobic e...
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ژورنال
عنوان ژورنال: Bulletin of the Australian Mathematical Society
سال: 2007
ISSN: 0004-9727,1755-1633
DOI: 10.1017/s0004972700039769