The 1st step initiation essential for allergen-specific IgE antibody production upon the 2nd step: Induction of non-specific IgE+small B cells containing secondly-sensitized allergen-specific ones in mice firstly-sensitized with an allergen
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چکیده
منابع مشابه
Induction and regulation of allergen-specific IgE
The immune response is characterized by an initial rapid activation of the innate defence system, geared at recognizing common structures shared by many microorganisms. This innate immune response is a prerequisite to mount a highly antigenspecific adaptive immune response consisting of T-cell differentiation into effector subsets and B-cell differentiation into antibody-secreting plasma cells....
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Allergen-specific immunotherapy is a potentially disease-modifying therapy that is effective for the treatment of allergic rhinitis/conjunctivitis, allergic asthma and stinging insect hypersensitivity. However, despite its proven efficacy in these conditions, it is frequently underutilized in Canada. The decision to proceed with allergen-specific immunotherapy should be made on a case-by-case b...
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gen tolerance. In this regard, animal models represent very helpful tools to analyze the immune effects of AIT in more detail since they allow investigators to focus on certain aspects when evaluating the immune mechanisms of tolerance induction, and can thus close a gap between in vitro analysis and immunological studies in humans [10] . A variety of mouse models have been developed to study t...
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ژورنال
عنوان ژورنال: Microbiology and Immunology
سال: 2018
ISSN: 0385-5600
DOI: 10.1111/1348-0421.12558