Thallium Induced Sub-chronic Toxicity Profile in Wistar Rats

Thallium (Tl) is one of the most toxic heavy metals affecting both humans and animals, yet least studied for its toxicological effects. A total 40 male Wistar rats were randomly divided into four Groups with 10 in each Group. Group I received distilled water only served as a control. II, III, IV thallium sulfate (I) at 0.48, 0.93, 1.33 mg/kg body weight, respectively, drinking 90 days. In rats, lethargy, dehydration, weakness, mild diarrhea, weight loss 100% morality rat noted. II III showed significant reduction cholesterol, phosphorus, triglyceride level, absolute relative spleen weight. Microscopically, found to cause lymphoid depletion white pulp all treatment Groups. kidney tubular necrosis, cytoplasmic vacuolation or clearing tubules, cast, thrombosis found. Dose dependent hyperkeratosis was non-glandular stomach three treated conclusion, spleen, primarily affected organs sub-chronic toxicity.