Thalidomide, A Rational Agent for Treatment of Multicentric Reticulohistiocytosis

Treatment of multicentric reticulohistiocytosis with etanercept.

An otherwise healthy 46-year-old man presented with a 1-year history of an ill-defined acral eruption that had evolved over several weeks into reddish-brown papules and nodules, together with a progressive inflammatory polyarthritis. Skin lesions ranging from several millimeters to several centimeters in diameter were present on the dorsal and palmar aspects of the hands (Figure 1) and on the f...

Progressive multicentric reticulohistiocytosis.

Multicentric Reticulohistiocytosis: A Reason for Erosive Arthritis

Multicentric Reticulohistiocytosis (MRH) is a rare histiocytic disorder that primarily involves the skin and joints but can affect multiple visceral organs. A female patient presented a characteristic papulonodular skin eruption and polyarthritis with positive Antinuclear Antibody (ANA), and skin biopsy findings demonstrated classic features of MRH. The patient’s clinical manifestations were in...

multicentric reticulohistiocytosis: a case report

multicentric reticulohistiocytosis (mrh) is a rare proliferative histiocytic disease of ‎unknown cause with potentially disabling nature. primary manifestations are involvement ‎of skin and joints. the articular destruction can lead to permanent joint deformities. our ‎patient was a 47 year-old woman with bilateral symmetrical polyarthritis and reddish- ‎brown papulonodular cutaneous lesions. t...

Successful Treatment of Multicentric Reticulohistiocytosis with Adalimumab, Prednisolone and Methotrexate.

Multicentric reticulohistiocytosis (MRH) is a rare systemic disorder belonging to non-Langerhans cell histiocytosis, which is characterized by severe destructive arthritis and multiple skin nodules. It is thought that proinflammatory cytokines, such as tumour necrosis factor-α (TNF-α), interleukin 1β (IL-1β), IL-6 and IL12 secreted by monocytes and macrophages, may be associated with the pathog...