Thalassaemia of intermediate severity resulting from the interaction between alpha- and beta-thalassaemia.

Prenatal diagnosis of thalassaemia major resulting from Lepore/ beta-thalassaemia genotype.

Antenatal diagnosis was carried out in a pregnancy at risk for beta-thalassaemia major/intermedia, resulting from the Lepore/ beta-thalassaemia genotype, by globin chain synthesis analysis on fetal blood obtained by placentocentesis at 19 weeks' gestation. As there was no radioactive incorporation in the beta-region, the fetus was considered to be a Lepore/ beta-thalassaemia genetic compound an...

Screening for beta thalassaemia

Iron state in alpha and beta thalassaemia trait.

The iron state was examined in two groups of pregnant women who were carriers of alpha and beta thalassaemia genes. In both groups the haematological expression of the disease--namely, haemoglobin and mean cell haemoglobin concentrations--was nearly identical. In patients with alpha thalassaemia the ferritin concentrations and percentage of ferritin deficiency was the same as in normal pregnant...

Interaction of Beta-thalassaemia and Hereditary Persistence of Foetal Haemoglobin.

Hereditary persistence of foetal haemoglobin (HPFH) is a term used to describe an inherited high level of Hb-F which is present throughout life and is not associated with anaemia. In that respect and by showing interaction with the S and C variants of adult haemoglobin, it resembles ,3-thalassaemia, and at one time it was described as 'non-microcythaemic thalassaemia'. There are, however, 3 fun...

Survival in beta-thalassaemia major in the UK: data from the UK Thalassaemia Register.

About 50% of UK patients with beta-thalassaemia major die before the age of 35 years, mainly because conventional iron-chelation therapy is too burdensome for full adherence. Patients require an individually-tailored treatment plan incorporating new, more tolerable approaches.