Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters
نویسندگان
چکیده
منابع مشابه
Whole-cell and acellular pertussis vaccination programs and rates of pertussis among infants and young children.
BACKGROUND The transition from a whole-cell to a 5-component acellular pertussis vaccine provided a unique opportunity to compare the effect that each type of vaccine had on the incidence of pertussis, under routine conditions, among children less than 10 years of age. METHODS Analyses were based on passive surveillance data collected between 1995 and 2005. The incidence of pertussis by year ...
متن کاملWhole-cell and acellular pertussis vaccines.
OBJECTIVE To provide a review of pertussis vaccines, including information on efficacy, adverse reactions, and antibody production following administration of both whole-cell and acellular pertussis vaccines. DATA SOURCES A MEDLINE search and extensive review of journals was conducted to identify the information for this review. DATA EXTRACTION Pertinent studies reporting experience with pe...
متن کاملPertussis epidemic despite high levels of vaccination coverage with acellular pertussis vaccine.
INTRODUCTION We describe the pertussis epidemic, based only on confirmed whooping cough cases. We have analyzed data on the diagnosis, epidemiology and vaccine history in order to understand the factors that might explain the trends of the disease. METHODS A descriptive study of the confirmed pertussis cases reported during 2011 in the Vallès region (population 1,283,000). Laboratory criteria...
متن کاملPertussis-specific cell-mediated immunity in infants after vaccination with a tricomponent acellular pertussis vaccine.
The aim of this study was to investigate pertussis-specific cell-mediated immunity in infants vaccinated with a tricomponent acellular vaccine. Infants were investigated during a primary vaccination schedule from the third month of life to the sixth month as well as before and after a booster at 15 to 24 months. This is the first report of specific cell-mediated immune responses to pertussis-re...
متن کاملLichen planus following tetanus–diphtheria–acellular pertussis vaccination: A case report and review of the literature
Lichen planus is an inflammatory dermatosis with a prevalence of approximately 1%. Recent meta-analyses show that patients with hepatitis C virus have a 2.5- to 4.5-fold increased risk of developing lichen planus. Lichen planus has also followed vaccinations and has specifically been attributed to the hepatitis B vaccine, the influenza vaccine, and the tetanus-diphtheria-acellular pertussis vac...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2018
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci121309